I just got the PS3IR-PRO and the power-on seems to work erratically with my Harmony One. I'm using the Sony PS3 profile to get the good icons, and I followed the instructions elsewhere in this forum to add the special PowerOff commend using the Pronto codes, etc. The power-off function appears to be rock-solid in repeatability, but power up fails about once in maybe every 3 or 4 power-up cycles, though pressing Help on the remote always powers up the PS3. There's an adjustment in the Harmony software that lets you change the amount of time it takes for a device to accept a new command (in ms) I went all the way from 0ms to 3000ms and it seemed to make little difference. (BTW I'm running version 7.4.3 of the Harmony software and I suspect it's been dumbed down a bit.) The PS3 is on version 2.41 and I'll presume my PS3IR-PRO is on version 1.09 since I just got the device.